Fri Jan 31 2025

31 articles - From Friday Jan 24 2025 to Friday Jan 31 2025

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Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…


Meta-analysis

meta-analyses and systematic reviews

Liver Transpl

Machine perfusion strategies in Liver Transplantation: A systematic review, pairwise, and network meta-analysis of randomized controlled trials.

Our meta-analysis showed that HOPE/dual-HOPE is a promising alternative to SCS for donor liver preservation. These new techniques can help expand the donor pool with similar or even better post-LT outcomes.

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Original articles

RCT, clinical trials, retrospective studies, etc…

Am J Clin Nutr

Breastfeeding and infant growth in relation to childhood overweight - A longitudinal cohort study.

Longer duration of exclusive breastfeeding was associated with decreased risk of being overweight, while accelerated infant growth was associated with increased risk. Children with accelerated infant growth who were never breastfed had the highest risk of overweight at 5-9 years of age, while there was no association if the infants were exclusively breastfed >4 months.

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Characterization of gene-environment interactions for vitamin D through variance quantitative trait loci: a UK Biobank-based genetic epidemiology study.

Through the lens of vQTLs, we identified additional gene-environment interactions affecting vitamin D status in addition to season of measurement. These findings may provide new insights into the etiology of vitamin D deficiency and encourage personalized prevention and management of associated diseases for at-risk individuals.

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Consuming Pecans as a Snack Improves Lipids/Lipoproteins and Diet Quality Compared to Usual Diet in Adults at Increased Risk for Cardiometabolic Diseases: A Randomized Controlled Trial.

clinicaltrials. gov NCT05071807.

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Describing the landscape of nutrition- and diet-related randomized controlled trials: meta-research study of protocols published between 2012 and 2022.

The number of protocols for nutrition- or diet-related RCTs published is increasing, supporting the raising awareness and the importance of promoting these publications. The support and mention of relevant reporting guidelines by journals and researchers, respectively, remain far from ideal.

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Planetary Health Diet Index in relation to mortality in a prospective cohort study of U.S. Black females.

Adherence to a diet that has been shown to benefit the planet was associated with a lower risk of mortality among Black females, primarily driven by reduction in CVD-specific mortality risk.

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Protein glycation compromises the bioavailability of milk protein-derived lysine in vivo in healthy adult males: a double-blind randomized cross-over trial.

A high level of milk protein glycation strongly reduces post-prandial plasma lysine availability in vivo in humans. Industrial processing and storage of (milk) protein products can strongly modulate protein bioavailability and, as such, lower the nutritional value of a protein source.

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Whole cranberry fruit powder supplement reduces the incidence of culture-confirmed urinary tract infections in females with a history of recurrent urinary tract infection: A 6-month multicenter, randomized, double-blind, placebo-controlled trial.

This study showed that whole cranberry powder capsules do not impact safety markers and reduce the incidence of culture-confirmed UTI and several other UTI-related outcomes in healthy females with rUTI history. Clinical trials registration Registered with clinicaltrials.gov (NCT03042273).

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Inflamm Bowel Dis

Circulating and Magnetic Resonance Imaging Biomarkers of Intestinal Fibrosis in Small Bowel Crohn's Disease.

Clinically available and exploratory circulating and MRI biomarkers are associated with the degree of inflammation versus fibrosis in CD ileal resections. With further validation, these biomarkers may be used to guide medical and surgical decision-making for refractory CD.

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Inflammation-Induced Th17 Cells Synergize with the Inflammation-Trained Microbiota to Mediate Host Resiliency Against Intestinal Injury.

Fecal microbiota transfer showed that the inflammation-trained microbiota was necessary for protection, likely by maintaining protective Th17 cells in situ. Inflammation can generate protective Th17 cells that synergize with the inflammation-trained microbiota to provide host resiliency against subsequent injury, indicating that inflammation-induced Th17 TRM T cells are heterogenous and contain protective subsets.

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Safety and Efficacy of Fecal Microbiota, Live-jslm (REBYOTA®), for the Prevention of Recurrent Clostridioides difficile Infection in Participants With Inflammatory Bowel Disease in PUNCH CD3-OLS.

The results of this subgroup analysis of PUNCH CD3-OLS suggest RBL is safe and efficacious in patients with IBD.

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Serum Periostin is Able to Stratify Type 2-Dominant Ulcerative Colitis.

Periostin can be a useful biomarker to stratify type 2-dominant UC patients, thereby predicting the efficacy of oral prednisolone. Moreover, periostin plays an important role in the setting of type 2-dominant UC.

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J Crohns Colitis

A pro-inflammatory diet is associated with growth and virulence of Escherichia coli in pediatric Crohn's disease.

A negative association between metabolites of fatty acid metabolism and HEI was found. In total, our results suggest that a pro-inflammatory diet may potentiate hallmarks of the inflammation-associated dysbiosis in CD and highlight the need for microbiome-targeted dietary interventions optimizing the anti-inflammatory potential of habitual diet in the management of pediatric CD.

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Intestinal Epithelial Ptpn23 Is Essential For Gut Barrier Integrity And Prevention Of Fatal Bacterial Translocation.

The absence of PTPN23 in IECs leads to lethal dysregulation of intestinal homeostasis, triggered by bacterial infiltration due to defects in the intestinal epithelial barrier and impaired IgA transcytosis. Thus, we identify PTPN23 as a novel key player in preserving intestinal epithelial homeostasis, ultimately preventing bacterial overgrowth and excessive immune activation in the intestine.

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Janus kinase inhibitors in the management of acute severe ulcerative colitis: a comprehensive review.

JAKi seem to be a promising treatment option for ASUC, with both tofacitinib and upadacitinib achieving colectomy-free rates of approximately 80%. Further studies are essential to define whether JAKi can replace cyclosporine/infliximab as second line therapy for the medical management of ASUC, or whether they can even be used as initial treatment in place of intravenous corticosteroids.

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Lysophosphatidylcholine-Induced Aberrant Adipogenesis in Mesenchymal Stem Cells and Impaired Antibacterial Function in Adipocytes of Creeping Fat.

These findings were consistent in the TNBS-treated mouse model, where increased LPC levels in the blood, and a significant reduction in SAA½-positive adipocytes were noted. LPC-induced aberrant adipogenesis in CF is a newly identified pathological feature in CD patients and a potential therapeutic target.

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The Impact of Advanced Medical Therapies on Time to Resection and Colorectal Cancer Outcomes in Ulcerative Colitis Patients Undergoing Colectomy.

Despite increased usage of advanced medical therapies, time to resection and CRC rates have remained unchanged in UC patients undergoing colectomy over the past two decades. Advanced therapy patients had higher incidental cancers rates, associated with decreased CRC-survival. Awareness of timely colectomy is crucial for this group.

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Liver Transpl

Evaluating allograft risk models in organ transplantation: Understanding and balancing model discrimination and calibration.

Our goal in this perspective is to offer advice to transplant professionals about how to evaluate a prediction model, focusing on the key aspects of discrimination and calibration. We use liver allograft assessment as a paradigm example, but the lessons pertain to other scenarios too.

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Pancreas

Preoperative Anemia as a Prognostic Risk Factor for Inferior Oncological Survival Following Resection for Pancreatic Ductal Adenocarcinoma.

Preoperative anemia was shown to be an independent risk factor for inferior oncological survival after resection for PDAC. These results support the need for increased awareness regarding the potential adverse effects of preoperative anemia on oncological outcomes in PDAC.

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Pancreatology

Pancreatectomies with vein resection: Two large institutions' experience of East and West.

We report favorable outcomes of PAVR for pancreatic cancer from two high-volume centers in the east and west. Primary end-to-end anastomosis was safe and feasible even if the length of PV/SMV resection was 5 cm or more.

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Safety, tolerability and therapeutic efficacy of anti-inflammatory drug pirfenidone in acute pancreatitis patients: Protocol for a randomized pilot clinical trial.

There is an urgent need to identify novel therapies for AP. This pilot clinical trial may become the basis of a larger study to analyze the efficacy of pirfenidone in patients with AP.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Pancreatology

Tailoring endoscopy for infected pancreatic necrosis: DEN or PEN or combined?

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Inflamm Bowel Dis

Bridging the Gap Between Explanatory and Pragmatic Trials in Inflammatory Bowel Disease.

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Resting-State Functional Connectivity of the Cerebellum Differs Between Persons With Inflammatory Bowel Disease and Healthy Controls in Relation to Executive Function.

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Liver Transpl

After the curtain was raised, Hepatitis C plays on: Celebrities and Hepatitis C.

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Fellows' Corner.

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From core to surface: Expanding the donor pool with Hepatitis B Surface antigen positive liver allografts.

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Less salt and more water for children-not just dietary, but transplant management too.

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Letter to the Editor: Monoacylglycerol acyltransferase 1 in fatty liver ischemia-reperfusion injury: Exacerbation or mitigation?

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Racial and ethnic disparities in extended criteria allograft use for liver transplantation.

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Trends in surgical volume and mortality by surgery type among patients with cirrhosis: A veterans affairs study.

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Letters&Replies

Letters to the editors and authors’ replies